1-Boc-4-[methoxy(methyl)carbamoyl]piperidine

1-Boc-4-[methoxy(methyl)carbamoyl]piperidine - Names and Identifiers

Name	1-Boc-4-[methoxy(methyl)carbamoyl]piperidine
Synonyms	N-Boc-4-(Methoxy-Methyl-Carbamoyl)Piperidine 1-BOC-4-(METHOXY-METHYL-CARBAMOYL)PIPERIDINE N-BOC-4-(METHOXY-METHYL-CARBAMOYL)PIPERIDINE 1-Boc-4-[methoxy(methyl)carbamoyl]piperidine 1-Boc-4-(Methoxy-Methyl-Carbamoyl)Piperidine N'-Boc-N-methoxy-N-methylpiperidine-4-carboxamide tert-Butyl 4-[methoxy(methyl)carbamoyl]piperidine-1-carboxylate Tert-Butyl 4-[Methoxy(Methyl)Carbamoyl]Piperidine-1-Carboxylate TERT-BUTYL 4-(N-METHOXY-N-METHYLCARBAMOYL)PIPERIDINE-1-CARBOXYLATE Tert-Butyl 4-(N-Methoxy-N-Methylcarbamoyl)Piperidine-1-Carboxylate tert-Butyl 4-(N-Methoxy-N-MethylcarbaMoyl)-1-piperidinecarboxylate 4-(Methoxy-methyl-carbamoyl)-piperidine-1-carboxylicacidtert-butylester 4-(Methoxy-Methyl-Carbamoyl)-Piperidine-1-Carboxylicacidtert-Butylester 1,1-Dimethylethyl 4-[[methyl(methoxy)amino]carbonyl]-1-piperidinecarboxylate
CAS	139290-70-3
InChI	InChI=1/C13H24N2O4/c1-13(2,3)19-12(17)15-8-6-10(7-9-15)11(16)14(4)18-5/h10H,6-9H2,1-5H3

1-Boc-4-[methoxy(methyl)carbamoyl]piperidine - Physico-chemical Properties

Molecular Formula	C13H24N2O4
Molar Mass	272.34
Density	1.106±0.06 g/cm3(Predicted)
Melting Point	71.0 to 75.0 °C
Boling Point	150°C/0.9mmHg(lit.)
Flash Point	161.723°C
Solubility	Chloroform, Dichloromethane, Ethyl Acetate, Methanol
Vapor Presure	0mmHg at 25°C
Appearance	pale yellow oily
Color	Pale Yellow
pKa	-2.31±0.40(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.487
MDL	MFCD07368262

1-Boc-4-[methoxy(methyl)carbamoyl]piperidine - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	22 - Harmful if swallowed

1-Boc-4-[methoxy(methyl)carbamoyl]piperidine - Upstream Downstream Industry

Raw Materials	1,4-Piperidinedicarboxylic acid N-Boc-Piperidine-4-carboxylic acid methyl ester DI-TERT-BUTYL ETHER Ethyl N-Boc-piperidine-4-carboxylate N-BOC-piperidine-4-carboxylic acid N-methoxymethylamine Ethyl 4-piperidinecarboxylate Di-tert-butyl dicarbonate Isonipecotic acid
Downstream Products	4-ACETYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-BOC-PIPERIDIN-4-YLPROPIONIC ACID

1-Boc-4-[methoxy(methyl)carbamoyl]piperidine - Introduction

1-Boc-4-[methoxy(methyl) carbamoyl] piperidine is an organic compound whose chemical name is tert-butyl 4-(methoxy) amino formylpiperidine-1-carboxylate, often abbreviated as Boc-MAM piperidine.

Nature:
1-Boc-4-[methoxy (methyl) carbamoyl] piperidine is a solid, usually white crystal or crystalline powder. It has high thermal stability and solubility, and can be dissolved in conventional organic solvents.

Use:
1-Boc-4-[methoxy (methyl) carbamoyl] piperidine is a common organic synthesis intermediate. It is commonly used in the synthesis of pharmaceuticals, pesticides, dyes and other organic compounds. It can be used as a protective group or functional group introduction agent, and play an important role in organic synthesis reaction.

Preparation Method:
1-Boc-4-[methoxy (methyl) carbamoyl] piperidine can be synthesized by a series of chemical reactions. The specific preparation method may vary depending on the reaction conditions and laboratory requirements. A common synthetic method is the reaction of piperidinyl 4-carbamate with methanol and methylmagnesium iodide, followed by the addition of tert-butylphosphonate in acetonitrile.

Safety Information:
1-Boc-4-[methoxy (methyl) carbamoyl] piperidine is a chemical that requires careful handling in a laboratory or industrial environment. It may be irritating to the eyes and skin, so it is necessary to wear appropriate protective equipment when handling. In addition, proper storage methods should be followed and contact with oxidants and other hazardous chemicals should be avoided. Specific safety operation procedures should be carried out according to the safety regulations of the laboratory or factory. Observe relevant regulations and guidelines when using or disposing of this compound.

Last Update：2024-04-09 20:52:54

Shanghai Macklin Biochemical Co., Ltd

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